Clinical Studies

MGCPQQ® is a natural source of pyrroloquinoline quinone created using a patented fermentation process that has been well-studied and documented through scientific research and peer-reviewed literature. Its functions have been fully characterized and widely tested in approximately 1,000 animal and human studies.

A series of clinical studies suggest the ingredient can activate mitochondrial biogenesis, meaning it can energize the mitochondria in cells. Studies show that MGCPQQ® can also potentially support Nerve Growth Factor (NGF), and that the ingredient may play a role in nerves and other organs growing or recovering after being damaged, (Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes, Murase K., Hattori A., Kohno M. & Hayashi K., 1993). Neurons are susceptible to lethal damage from oxidative stress, and neuronal death is regarded as a causal factor in some cognitive disorders. By functioning as an antioxidant as well as an NGF enhancer, the ingredient has shown to inhibit neurotoxicity.

MGCPQQ Infographics

Download MGCPQQ Brain Health Infographic

Download MGCPQQ Energy Infographic

Download MGCPQQ Clinical Studies Infographic

References

MGCPQQ Reports

Download the MGCPQQ Mitochondria Bulletin

History

1979 The Pyrroloquinoline Quinone (PQQ) compound is discovered as coenzyme of oxidoreductase.

1980s Mitsubishi Gas Chemical begins supplying PQQ disodium salt.

2003 A research group in Japan suggests that the ingredient has the potential to become a new vitamin.

2008 MGCPQQ® (BioPQQ®) is successfully filed as a New Dietary Ingredient (NDI) with the U.S. Food & Drug Administration (FDA), and Mitsubishi Gas Chemical becomes the first company to utilize PQQ in food applications. To this day, MGCPQQ® (BioPQQ®) remains the only ingredient of its kind with NDI notification.

2014 MGCPQQ® (BioPQQ®) is certified as food ingredient for food application by Japan’s MHLW (Ministry of Health, Labour and Welfare).

2017 The EFSA (European Food Safety Authority) completes a safety evaluation on MGCPQQ®(BioPQQ®), and the evaluation report is made public.

2018 MGCPQQ® (BioPQQ®) is certified by the Informed-Choice and Informed-Sport quality assurance programs, ensuring that the ingredient is manufactured to high-quality standards and that every batch is tested for substances banned from the World Anti-Doping Agency (WADA) list. The certifications attest to the ingredient’s quality and manufacturing integrity and reassure athletes that MGCPQQ® (BioPQQ®) is safe to use.

2018 MGCPQQ® (BioPQQ®) is listed on the EU’s Approved List of Novel Foods as PQQ, and the ingredient is approved as a food supplement. The Novel Foods approval is exclusive to MGCPQQ®.

Present MGCPQQ®(BioPQQ®) is widely used as a food supplement for its various health maintenance functionalities in U.S.A. and Japan, and the ingredient is made available for sale in Europe for the first time.

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